Publié par Preuves & Pratiques


Démence avec corps de Lewy (DCL) et maladie d'Alzheimer (MA), traits distinctifs.

Résultats d'une étude incluant 290 participants (77,6 ans) : outre les hallucinations visuelles, les traits caractérisant la DCL, repérables par l'Echelle de Blessed*, comprennent
-la diminution de la réponse émotionnelle (p = 0,004),
-le renoncement aux hobbies (p = 0,01),
-l'apathie croissante (p = 0,03) et
-l'hyperactivité inutile (p = 0,003).

Cette passivité globale de la personnalité aurait plus de probabilité de s'exprimer dans la DCL que dans la MA

(p = 0,001). * échelle évaluant la démence .

Galvin & Coll., Neurology, 29 mai 2007 ; 68 : 1895-1901.


Personality traits distinguishing dementia with Lewy bodies from Alzheimer disease

James E. Galvin, MD, MPH, Heather Malcom, David Johnson, PhD and John C. Morris, MD
From the Alzheimer Disease Research Center (J.E.G., H.M., D.J., J.C.M.) and Departments of Neurology (J.E.G., D.J., J.C.M.), Anatomy and Neurobiology (J.E.G.), and Pathology and Immunology (J.C.M.), Washington University School of Medicine, St. Louis, MO.

Address correspondence and reprint requests to Dr. James E. Galvin, Alzheimer Disease Research Center, Washington University School of Medicine, 4488 Forest Park, Suite 130, St. Louis, MO 63108

Objective: To identify personality traits that distinguish dementia with Lewy bodies (DLB) from Alzheimer disease (AD).

Methods: We examined 290 participants enrolled in a longitudinal study (nondemented control = 34, DLB = 128, AD = 128) followed to autopsy. As part of the annual interview with the collateral source, the clinician asked about specific changes in personality, interests, and drives based on items from the Blessed Dementia Scale (BDS). Statistical analysis was performed using 2 and Fisher exact tests. Factor analysis was performed to determine underlying structure and receiver operating characteristic curves assessed the ability for each of three derived factors to discriminate DLB from AD.

Results: The sample was evaluated for a mean of 4.8 visits (range 1 to 14) with a mean age of 77.6 ± 9.9 years. The participants' cognitive status ranged from nondemented (Clinical Dementia Rating [CDR] 0) through all stages of dementia (CDR  0.5). Personality traits that distinguished DLB included diminished emotional responsiveness (p = 0.004), relinquishing hobbies (p = 0.01), growing apathy (p = 0.03), and purposeless hyperactivity (p = 0.003). Factor analyses of the BDS revealed a PASSIVE factor (diminished emotional responsiveness, relinquished hobbies, growing apathy, and purposeless hyperactivity) explaining 10.4% of variance and that DLB was more likely to manifest these personality traits than AD (p = 0.001). The PASSIVE factor discriminated DLB from AD (area under the curve = 0.61, 95% CI: 0.54 to 0.68, p = 0.006). Any change in personality is associated with the presence of visual hallucinations.

Conclusions: Our results suggest that incorporating a brief, simple inventory of personality traits may improve the identification of individuals with dementia with Lewy bodies.

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